This technique is widely known for its beneficial effects on palmar sweating. It can be annoying and embarrassing for patients who have sweat dripping from their hands. This medical condition is a stressful issue that humiliates patients and makes them lose their self-confidence. Palmar hyperhidrosis (excessive hand sweating) can affect patients' daily routines and social life. Botox injections reduce the ability of nerves to trigger sweat glands to produce sweat.

Indications for Botox treatment of sweating hands include wet or clammy hands, excessive sweating that causes infection, and excessive sweating that leaves wet marks on clothes.